Over the last years, there was an increasing inte the rest in keeping suitable microblimatic conditions for the preservation of artefacts: artefacts preservation requeriments may diverge from those of the museums visitors, willing to enjoy the works of art in a situation of psycho-physical wellness. The HVAC designers and engineers will have then to cooperate closely with the curator, in order to define a compromise between conflicting environmental requeriments. In particular at the stage of air-conditioning system design or retrofit, it is extremely important tp carry out a series of preliminary analysis to evaluate and monitor the existing environmental conditions and to anticipatory simulate and predict the post-intervention conditions. To this aim, advanced fluid-dynamic investigation tools (Computational Fluid Dynamic [CFD] techniques) enable to deal with the specificity of such topics and provide a useful decision-making support.